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Keratoconus and coexisting atopic disease.

A Rahi, P Davies, M Ruben

    The British Journal of Ophthalmology
    |December 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

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    Patients with keratoconus (an eye condition) show a higher prevalence of atopic disease (allergic conditions) and elevated immunoglobulin E (IgE) levels. These findings suggest a significant link between keratoconus and atopy.

    Area of Science:

    • Ophthalmology
    • Immunology
    • Genetics

    Background:

    • The link between keratoconus and atopic disease is debated, with prior studies yielding conflicting results.
    • Atopy is frequently associated with altered immunoglobulin levels, particularly immunoglobulin E (IgE).

    Purpose of the Study:

    • To investigate the immunological profiles of keratoconus patients to assess the coexistence of atopy.
    • To determine if atopic traits are more prevalent in individuals with keratoconus.

    Main Methods:

    • A cohort of 182 keratoconus patients was compared to a matched control group.
    • Serum levels of immunoglobulin E (IgE), immunoglobulin G (IgG), and immunoglobulin M (IgM) were measured.
    • Patient histories were assessed for the presence of atopic disease.

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    Main Results:

    • A history of atopy was reported in 35% of keratoconus patients versus 12% in controls.
    • Significantly elevated serum IgE levels were observed in keratoconus patients (P < 0.001), especially those with atopy.
    • Elevated serum IgG and IgM levels were noted, while IgA levels remained normal.

    Conclusions:

    • Atopic traits are more common in patients with keratoconus than in the general ophthalmic population.
    • Elevated serum IgE levels support an association between keratoconus and atopy.