Anti-ovalbumin sensitizing ability of influenza vaccines in guinea pigs

The anti-ovalbumin sensitizing ability of four highly purified commercial influenza vaccines was tested in guinea pigs by means of passive cutaneous anaphylaxis. Aluminimum-adsorbed and fluid vaccines as well as pretreatments by one or two subcutaneous inoculations were compared. The two adsorbed vaccines induced significant sensitization after just one inoculation while the two fluid vaccines revealed their sensitizing ability almost exclusively after repeated administration.