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Related Experiment Videos

Hemoglobin Tak in a newborn Malay.

L E Lie-Injo, Z I Randhawa, J Ganesan

    Hemoglobin
    |January 1, 1977
    PubMed
    Summary

    Hemoglobin Tak, a rare genetic condition, was identified in a newborn with severe jaundice. Affected individuals showed increased red blood cell resistance, suggesting a shared genetic origin across populations.

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    Area of Science:

    • Genetics
    • Hematology
    • Molecular Biology

    Background:

    • Neonatal jaundice can be caused by various factors, including hemoglobinopathies.
    • Hemoglobin Tak is a rare, inherited condition characterized by an elongated beta-globin chain.

    Observation:

    • A 4-day-old Malay newborn presented with severe neonatal jaundice.
    • The newborn and their heterozygous mother were diagnosed with Hemoglobin Tak, featuring an 11-residue C-terminal elongation of the beta chain.

    Findings:

    • The affected Malay family exhibited increased erythrocyte resistance to hypotonic saline solutions and mild anisopoikilocytosis.
    • The genetic mutation for Hemoglobin Tak in this Malay family may share a common origin with previously reported Thai families.

    Implications:

    • This finding expands the known ethnic distribution of Hemoglobin Tak.
    • Understanding the genetic origins of hemoglobinopathies is crucial for diagnosis and genetic counseling.
    • Further research is needed to confirm the shared ancestry of the abnormal gene in different populations.

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