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Related Experiment Videos

Cell replacement and changing transport function in the neonatal pig colon.

L G Jarvis, G Morgan, M W Smith

    The Journal of Physiology
    |December 1, 1977
    PubMed
    Summary

    Newborn pig colon actively concentrates methionine, but this ability is lost within days as new cells replace old ones. This transient amino acid transport may be crucial for early piglet development.

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    THE FINE STRUCTURE AND DEVELOPMENT OF THE COMPANION CELL OF THE PHLOEM OF ACER PSEUDOPLATANUS.

    The Journal of cell biology·2009

    Area of Science:

    • Gastroenterology
    • Developmental Biology
    • Cell Biology

    Background:

    • The piglet colon's function during early post-natal development is not fully understood.
    • Methionine transport is essential for cellular function and growth.

    Purpose of the Study:

    • To investigate the capacity of the piglet colon to concentrate methionine post-birth.
    • To determine the developmental timeline of methionine transport in the piglet colon.
    • To explore the relationship between cell turnover and methionine transport.

    Main Methods:

    • In vitro incubation of pig colon with methionine-containing medium.
    • Autoradiography using 3H-labelled phenylalanine to track accumulation.
    • Radioactive thymidine incorporation to study cell mitosis and migration.

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  • Measurement of intracellular methionine concentration.

    • Main Results:

    • Newborn pig colon actively concentrates methionine, primarily in surface epithelial cells.
    • This methionine-concentrating ability diminishes within the first few days of post-natal life.
    • Cell replacement in the colonic crypts occurs with a turnover time of 105 hours, and newly formed cells appear unable to transport methionine.

    Conclusions:

    • The transient ability of the newborn pig colon to transport methionine is linked to the replacement of cells.
    • The underlying signal causing this functional change in post-natal cells requires further investigation.
    • This early amino acid transport mechanism may play a significant physiological role in piglets.