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Glucose Uptake Measurement and Response to Insulin Stimulation in In Vitro Cultured Human Primary Myotubes
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Occult glucose intolerance: incidence in a general population
California Medicine
|May 1, 1967
Summary
A study of 456 adults found that many had high blood sugar levels two hours after consuming glucose. These results suggest current diagnostic criteria for glucose challenges may need revision.
Area of Science:
- Endocrinology
- Metabolic Health
- Public Health
Background:
- Postprandial hyperglycemia is a key indicator of metabolic dysfunction.
- Current diagnostic thresholds for oral glucose tolerance tests are established but may not reflect diverse populations.
Purpose of the Study:
- To assess two-hour postprandial glycemic responses in a healthy adult community.
- To evaluate potential age and sex differences in glycemic responses.
- To inform potential revisions of diagnostic criteria for glucose challenges.
Main Methods:
- Oral glucose challenge with 100 gm of glucose administered to 456 healthy adults.
- Measurement of serum glucose levels at the two-hour postprandial sampling period.
- Analysis of glycemic responses stratified by age and sex.
Main Results:
- 32% of men and 36% of women exceeded 140 mg/dL serum glucose at two hours.
- Hyperglycemia prevalence increased with age in both sexes.
- Women under 50 showed a higher prevalence of elevated glucose levels compared to men.
Conclusions:
- A significant proportion of apparently healthy adults exhibit elevated postprandial glucose levels.
- Age and sex are important factors influencing glycemic responses.
- Existing criteria for interpreting oral glucose challenges may require re-evaluation.
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