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Penicillinase-producing Neisseria gonorrhoeae
Lancet (London, England)
|September 25, 1976
Summary
Penicillin G treatment failed for gonorrhoeal urethritis due to resistant Neisseria gonorrhoeae. The bacteria produced penicillinase, rendering the antibiotic ineffective.
Area of Science:
- Microbiology
- Infectious Diseases
- Antimicrobial Resistance
Background:
- Gonorrhoea, a sexually transmitted infection, is commonly treated with penicillin G.
- Urethritis is an inflammation of the urethra, often caused by bacterial infection.
Observation:
- A patient with gonorrhoeal urethritis experienced repeated treatment failures with penicillin G.
- The causative Neisseria gonorrhoeae strain was subjected to antimicrobial susceptibility testing.
Findings:
- Disc diffusion testing revealed complete resistance of the Neisseria gonorrhoeae strain to 10 µg of penicillin G.
- The resistant Neisseria gonorrhoeae strain was identified as a penicillinase producer.
Implications:
- Penicillinase production is a significant mechanism of penicillin resistance in Neisseria gonorrhoeae.
- This finding highlights the need for alternative treatment strategies for gonorrhoea in cases of penicillin resistance.