Related Experiment Videos
The surface antigens of Campylobacter sputorum subspecies mucosalis
Abstract:
Campylobacter sputorum subsp mucosalis is the vibrio associated with a group of porcine enteropathies in which it is believed the primary lesion is that of adenomatosis. The surface antigens of mucosalis were investigated and individual factor sera were produced; these were used to examine a range of field strains from adenomatosis, necrotic enteritis, regional ileitis and proliferative haemorrhagic enteropathy. Neither these not sequential isolants from the same farm showed any distinctive antigenic pattern and it is suggested that changes in the surface antigens take place during the intracellular existence of the organism.
Insights
Campylobacter sputorum subsp mucosalis causes porcine enteropathies. Surface antigen analysis of field strains did not reveal distinctive patterns, suggesting changes during intracellular existence.
Area of Science:
- Veterinary Microbiology
- Animal Pathology
- Bacterial Pathogenesis
Background:
- Campylobacter sputorum subsp mucosalis is implicated in porcine enteropathies, particularly adenomatosis.
- The primary lesion in these conditions is often adenomatosis, suggesting a specific host-pathogen interaction.
Purpose of the Study:
- To investigate the surface antigens of Campylobacter sputorum subsp mucosalis.
- To determine if distinct antigenic patterns correlate with different porcine enteropathies or farm isolates.
Main Methods:
- Production of individual factor antisera against surface antigens of Campylobacter sputorum subsp mucosalis.
- Serological examination of various field strains isolated from different porcine enteropathies (adenomatosis, necrotic enteritis, regional ileitis, proliferative haemorrhagic enteropathy).
- Analysis of sequential isolates from the same farm to assess antigenic stability.
Main Results:
- No distinctive antigenic patterns were identified among the examined field strains.
- Sequential isolates from the same farm did not exhibit unique antigenic profiles.
- The study did not find a clear correlation between surface antigen profiles and specific enteropathy types.
Conclusions:
- Surface antigen analysis alone does not differentiate field strains of Campylobacter sputorum subsp mucosalis associated with various porcine enteropathies.
- It is hypothesized that changes in surface antigens may occur during the intracellular phase of the organism's life cycle.
- Further research is needed to understand the role of surface antigens and potential antigenic variation in the pathogenesis of porcine enteropathies.