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Related Experiment Videos

Plasma cortisol concentration in newborn infants.

T Yoshida, Y Hattori, K Noda

    The Tohoku Journal of Experimental Medicine
    |December 1, 1977
    PubMed
    Summary

    Neonatal plasma cortisol levels rapidly decrease in the first three days post-delivery. Stressful deliveries initially elevate infant cortisol, but levels normalize by day three.

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    Area of Science:

    • Endocrinology
    • Neonatal Physiology
    • Pediatric Health

    Background:

    • Neonatal adaptation involves complex hormonal changes.
    • Plasma cortisol is a key stress biomarker in newborns.
    • Understanding cortisol dynamics is crucial for assessing infant well-being.

    Purpose of the Study:

    • To investigate plasma cortisol levels in neonates.
    • To examine the influence of delivery stress on neonatal cortisol.
    • To compare cortisol levels based on delivery type and infant health status.

    Main Methods:

    • Plasma cortisol was measured in cord and neonatal blood samples.
    • Infants were categorized by delivery type (spontaneous vaginal, oxytocin-induced vaginal) and birth weight (small-for-date, average-for-date).
    • Cortisol levels were assessed at different time points post-delivery and correlated with delivery stress and infant health indicators like hyperbilirubinemia.

    Main Results:

    • Neonatal cortisol concentrations declined sharply within the first three days postpartum, stabilizing thereafter.
    • Higher initial cortisol levels were observed in infants experiencing more stressful deliveries, normalizing by day three.
    • No significant difference in cortisol levels was found between spontaneous and oxytocin-induced vaginal deliveries.
    • Infants who were small-for-date or had hyperbilirubinemia exhibited lower plasma cortisol levels compared to average-for-date infants or those without hyperbilirubinemia.

    Conclusions:

    • Neonatal cortisol levels exhibit a distinct pattern of rapid decline and stabilization post-birth.
    • While delivery stress transiently impacts neonatal cortisol, this effect diminishes within three days.
    • Delivery method (spontaneous vs. oxytocin-induced vaginal) does not significantly alter neonatal cortisol profiles.
    • Lower cortisol levels in small-for-date infants and those with hyperbilirubinemia suggest altered stress response or metabolic pathways.

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