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Chromosome abnormality in rat leukemia induced by 7,12-dimethylbenz[a]anthracene
Science (New York, N.Y.)
|November 1, 1967
Abstract:
A high percentage of consistent chromosome abnormality, trisomy of the longest telocentric chromosome, was found in leukemias induced in rats of the Long-Evans strain by pulse doses of 7,12-dimethylbenz[a]anthracene. Cells with this abnormality were large, immature, and mononuclear and tended toward erythroblastic maturation.