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Myxovirus-like structures in a case of human chronic polymyositis
Abstract:
Intranuclear and intracytoplasmic aggregates of filaments with tubular structures and transverse striations occurred in muscle tissues biopsied from a patient with chronic polymyositis. The filamentous tubules bear a close resemblance to the incomplete form of myxovirus in which the envelope is missing. Three biopsies from the same patient, taken during a period of 1(1/2) years, all revealed these structures. This finding provides presumptive evidence that a chronic persistent viral infection may be involved in the pathogenesis of chronic polymyositis.
Insights
Researchers found viral-like structures in muscle biopsies from a patient with chronic polymyositis. This suggests a potential link between persistent viral infections and the development of this muscle disease.
Area of Science:
- Neurology
- Virology
- Pathology
Background:
- Chronic polymyositis is an idiopathic inflammatory myopathy.
- The etiology of chronic polymyositis remains largely unknown.
- Viral infections are suspected in some autoimmune and inflammatory conditions.