Removal of plasma bilirubin by hemoperfusion in dogs

The removal of plasma bilirubin by hemoperfusion in dogs with hepatic insufficiency was investigated. The quantity of bilirubin adsorbed from the plasma and from tissue flux during hemoperfusion was measured. The relationships of the mass of removed bilirubin, its initial concentration in the blood and the time of perfusion showed a good correlation. These studies have shown that the anion-exchange resin MCTI-2A used for removal of plasma bilirubin did not alter the electrolyte composition, acid-base balance and the concentration of other measured metabolites.