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Related Experiment Videos

Dopamine and schizophrenia.

T J Crow, E C Johnstone, J F Deakin

    Lancet (London, England)
    |September 11, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Neuroleptic drugs

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    Area of Science:

    • Neuroscience
    • Psychopharmacology

    Background:

    • Antipsychotic actions and extra-pyramidal side-effects of neuroleptic drugs correlate with blocking central dopaminergic transmission.
    • These effects are linked to dopaminergic mechanisms in the mesolimbic dopamine system (antipsychotic) and striatum (side-effects).

    Purpose of the Study:

    • To investigate the role of central dopaminergic transmission in the therapeutic and adverse effects of neuroleptic drugs.
    • To explore the relationship between amphetamine psychosis, schizophrenia, and dopamine system activity.

    Main Methods:

    • Review and synthesis of clinical, biochemical, and endocrine studies on neuroleptic drug actions.
    • Analysis of the dopaminergic hypothesis of schizophrenia.

    Main Results:

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    • Clinical evidence suggests dopaminergic overactivity is not essential for schizophrenia.
    • Amphetamine psychosis, while resembling schizophrenia, may involve excess dopamine release.

    Conclusions:

    • The primary defect in schizophrenia may not originate in the dopamine neuron itself.
    • Potential alternative mechanisms include supersensitive dopamine receptors in mesolimbic areas or a deficit in an opposing system.