Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

1alpha-hydroxyvitamin D3 in primary hyperparathyroidism.

I T Boyle, I Fogelman, B Boyce

    Clinical Endocrinology
    |December 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Use of Atlantic salmon, Salmo salar L., farm treatment data and bioassays to assess for resistance of sea lice, Lepeophtheirus salmonis, to emamectin benzoate (SLICE(®) ) in British Columbia, Canada.

    Journal of fish diseases·2012
    Same author

    Determination of trace-gas amounts in plumes by the use of orthogonal digital filtering of thermal-emission spectra.

    Applied optics·2010
    Same author

    Circulating fibroblast growth factor-23 increases following intermittent parathyroid hormone (1-34) in postmenopausal osteoporosis: association with biomarker of bone formation.

    Calcified tissue international·2010
    Same author

    The effect of weight and weight change on the long-term precision of spine and hip DXA measurements.

    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2010
    Same author

    Significant differences in UK and US female bone density reference ranges.

    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2010
    Same author

    Fibroblast growth factor-23 is associated with C-reactive protein, serum phosphate and bone mineral density in chronic kidney disease.

    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2009
    Same journal

    Supraphysiological Glucocorticoid Doses and Pitfalls of Annual Biomarker Monitoring in Adults With CAH.

    Clinical endocrinology·2026
    Same journal

    Subacute Thyroiditis in Denmark: A Nationwide Study of 1763 Cases.

    Clinical endocrinology·2026
    Same journal

    Pubertal Dynamics of Sertoli and Leydig Cell Dysfunction in Klinefelter Syndrome.

    Clinical endocrinology·2026
    Same journal

    Regarding Non-Classical Presentations of Rare Hereditary Hypoparathyroidism: A Case Series of CASR, GNA11, and GATA3 Mutations in Parathyroidology.

    Clinical endocrinology·2026
    Same journal

    Dual Metabolic Burden of Polyendocrine Metabolic Ovarian Syndrome (PMOS) and Gestational Diabetes in Pregnancy: Impact on Neonatal Anthropometry: Insights From the Born in Bradford Cohort.

    Clinical endocrinology·2026
    Same journal

    Preoperative CALLY Index for Identifying Atypical Parathyroid Tumors.

    Clinical endocrinology·2026
    See all related articles

    Pre-operative treatment with 1alpha-hydroxyvitamin D3 effectively prevents severe post-operative hypocalcaemia in patients with severe bone disease due to primary or tertiary hyperparathyroidism. This regimen is safe and recommended for routine use.

    Area of Science:

    • Endocrinology
    • Bone Metabolism
    • Surgical Management

    Background:

    • Primary hyperparathyroidism with severe bone disease, and tertiary hyperparathyroidism, often leads to severe, prolonged post-operative hypocalcaemia after surgical management.
    • This complication significantly impacts patient recovery and outcomes.

    Purpose of the Study:

    • To evaluate the efficacy of pre-operative 1alpha-hydroxyvitamin D3 in preventing post-operative hypocalcaemia.
    • To assess the impact of this treatment on pre-operative symptoms and hypercalcaemia exacerbation.

    Main Methods:

    • A short pre-operative course of 1alpha-hydroxyvitamin D3 was administered to seven patients with severe bone disease associated with hyperparathyroidism.
    • Clinical outcomes, including post-operative calcium levels and pre-operative symptoms, were monitored.

    Related Experiment Videos

    Main Results:

    • 1alpha-hydroxyvitamin D3 administration virtually eliminated severe and prolonged post-operative hypocalcaemia.
    • Pre-operative symptoms were diminished in patients where present.
    • No exacerbation of hypercalcaemia was observed during the pre-operative treatment period.

    Conclusions:

    • Pre-operative 1alpha-hydroxyvitamin D3 is a highly effective measure to prevent severe post-operative hypocalcaemia in patients with severe bone disease and hyperparathyroidism.
    • This therapeutic approach is safe, as it does not worsen hypercalcaemia, and is recommended for routine clinical practice.