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Related Experiment Videos

Multiple concomitant positive patch test reactions.

J C Mitchell

    Contact Dermatitis
    |December 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    False positive patch test reactions are common when multiple chemicals are tested simultaneously. Retesting revealed that initial positive reactions often decrease, indicating an overestimation of sensitivity with concomitant patch testing.

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    Area of Science:

    • Dermatology
    • Allergy and immunology
    • Patch testing

    Background:

    • Patch testing is a standard diagnostic tool for allergic contact dermatitis.
    • Concomitant patch testing involves applying multiple chemicals simultaneously to assess sensitization.
    • Interpreting patch test results requires careful consideration of reaction timing and potential false positives.

    Observation:

    • Thirty-five patients with 90 positive reactions to 28 chemicals at Day 2 were re-evaluated.
    • Re-evaluation occurred at Day 7, with results assessed at Day 9.
    • A significant decrease in positive reactions was observed upon retesting.

    Findings:

    • 60% of initial positive reactions remained positive at Day 9.
    • However, 42% of initial positive reactions became negative upon retesting.

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  • The total percentage of positivity decreased from 344% to 241% after retesting.

    • Implications:

    • Concomitant patch testing may lead to a high rate of false positive results.
    • The true index of chemical sensitivity can be falsely exaggerated by simultaneous testing.
    • This highlights the need for careful interpretation of patch test results, especially with multiple applications.