Monovalent influenza A/New Jersey/76 virus vaccines in asthmatic children: pulmonary function and skin tests for allergy
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Influenza A/New Jersey/76 virus vaccines were safe for asthmatic children, showing minimal allergic reactions and no negative impact on lung function. This study supports the use of influenza vaccines in pediatric asthma patients.
Area of Science:
- Pediatric Allergy and Immunology
- Vaccinology
- Respiratory Medicine
Background:
- Asthmatic children may have unique sensitivities to vaccinations.
- Influenza vaccination is crucial for individuals with chronic respiratory conditions.
Purpose of the Study:
- To evaluate the safety and tolerability of monovalent influenza A/New Jersey/76 virus vaccines in children with asthma.
- To assess potential allergic reactions and effects on pulmonary function following influenza vaccination in this population.
Main Methods:
- Eighty-eight asthmatic children (aged 6-16) received influenza A/New Jersey/76 vaccines.
- Skin testing for allergies to eggs and vaccines was performed on 41 children.
- Pulmonary function tests were conducted before and after immunization in 57 children.
Main Results:
- Only four children exhibited skin test reactivity to the vaccines.
- Three of the four reactive children showed sensitivity to only one vaccine preparation.
- No significant correlation was found between egg allergy and vaccine reactivity in most cases.
- No significant changes in pulmonary function were observed post-vaccination.
Conclusions:
- Monovalent influenza A/New Jersey/76 virus vaccines appear safe for use in asthmatic children.
- The vaccine demonstrated a low incidence of allergic reactions and did not adversely affect pulmonary function.
- Findings support the routine immunization of children with asthma against influenza.
Abstract:
Eighty-eight asthmatic children aged six to 16 years received monovalent influenza A/New Jersey/76 virus vaccines. Forty-one of these children were given skin tests for allergy to eggs and vaccines, and 57 were given pulmonary function tests before and after immunization. Only four children reacted to the vaccines in the skin tests, with three of these children reacting to only one of four test preparations. Only two of the four children showed a correlation between reactivity to vaccine and allergy to egg antigens. No significant changes in pulmonary function were demonstrated.