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Published on: February 19, 2019
Hepatitis B surface antigen in various liver diseases in Iraq
The Journal of Tropical Medicine and Hygiene
|December 1, 1977
Summary
Hepatitis B surface antigen (HBsAg) was detected in over 40% of patients with acute viral hepatitis and in 100% of those with active cirrhosis. This study highlights the prevalence of HBsAg in various liver diseases in Iraq.
Area of Science:
- Hepatology
- Virology
- Immunology
Background:
- Hepatitis B virus (HBV) infection is a significant global health concern.
- Hepatitis B surface antigen (HBsAg) is a key serological marker for HBV infection.
- Understanding HBsAg prevalence in different liver diseases is crucial for diagnosis and management.
Purpose of the Study:
- To determine the prevalence of HBsAg in patients with various liver diseases in Iraq.
- To investigate the correlation between HBsAg detection and specific liver conditions.
- To analyze the duration and patterns of HBsAg antigenaemia.
Main Methods:
- Counterimmunoelectrophoresis (CIEP)
- Passive haemagglutination (PHA) techniques
- Serological testing for HBsAg in 221 patients with liver diseases.
Main Results:
- HBsAg was detected in 40.8% of acute viral hepatitis cases, 40% of cryptogenic cirrhosis, 50% of chronic hepatitis, 100% of active cirrhosis, and 71.4% of hepatoma.
- Antigenaemia was highest early in acute hepatitis, lasting 3-16 weeks, with 3.4% persistent beyond 35 weeks.
- 31.3% of acute hepatitis cases showed no evidence of parenteral infection.
Conclusions:
- HBsAg is highly prevalent in active cirrhosis and hepatoma in the studied Iraqi population.
- Serological markers like HBsAg are vital for diagnosing and understanding the spectrum of liver diseases.
- Further research is needed to explore transmission routes and long-term implications of persistent antigenaemia.
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