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The systemic involvement in scleroderma.

A J Barnett

    The Medical Journal of Australia
    |November 12, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Scleroderma frequently affects multiple body systems, impacting joints and the gastrointestinal tract. Key indicators include hand X-ray abnormalities and pulmonary function changes.

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    Area of Science:

    • Rheumatology
    • Internal Medicine

    Background:

    • Scleroderma is a complex autoimmune disease characterized by skin thickening and fibrosis.
    • Systemic involvement beyond the skin is common but requires comprehensive evaluation.

    Purpose of the Study:

    • To investigate the prevalence and patterns of systemic involvement in patients with scleroderma.
    • To identify common clinical manifestations and diagnostic findings across different scleroderma subtypes.

    Main Methods:

    • Survey of 38 scleroderma patients (33 acrosclerotic, 5 diffuse).
    • Included symptom inquiry, physical examination, and extensive laboratory tests (radiology, ECG, pulmonary function, hematology, autoantibodies, biochemistry).

    Main Results:

    • Systemic involvement was nearly universal across both acrosclerotic and diffuse forms.

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  • Most common clinical sites: joints and gastrointestinal tract.
  • Frequent findings: positive neck test, telangiectasia, hand X-ray abnormalities (80%), pulmonary function and GI X-ray abnormalities (70%).

    • Conclusions:

    • Scleroderma commonly presents with widespread systemic disease affecting joints and the GI tract.
    • Diagnostic tools like hand X-rays and pulmonary function tests are crucial for identifying systemic involvement.