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[Serum insulin concentration, basal and during an standardized oral glucose tolerance test in healthy children

M J López, J Colomer

    Anales Espanoles De Pediatria
    |November 1, 1977
    PubMed

    Insights

    This study found that healthy children tend to have lower serum insulin levels, particularly fasting levels. A small percentage were identified as having low insulin secretion, with insulin levels positively correlating with age.

    Area of Science:

    • Pediatric Endocrinology
    • Metabolic Research
    • Human Physiology

    Background:

    • Understanding normal serum insulin concentration in children is crucial for diagnosing metabolic disorders.
    • Pediatric age significantly influences metabolic parameters, necessitating age-specific reference ranges.

    Purpose of the Study:

    • To investigate serum insulin concentrations in healthy children across different pediatric age groups.
    • To analyze insulin secretion patterns during an oral glucose tolerance test (OGTT).
    • To explore correlations between insulin levels, glucose metabolism, and age.

    Main Methods:

    • Measured serum insulin using radioimmunoassay and glucose via oxidative enzymatic procedures in 110 healthy children.
    • Administered a standardized oral glucose tolerance test (OGTT).
    • Utilized log-conversion for data analysis to achieve normal log distribution; calculated glucose and insulin areas and insulinogenic index.

    Main Results:

    • A general trend of low serum insulin values was observed, most pronounced in fasting levels.
    • 4.1% of the pediatric participants were classified as having hyposecretion (low insulin secretion).
    • A positive correlation was found between insulin levels and age, evident in both fasting and OGTT conditions.

    Conclusions:

    • Healthy children exhibit a tendency towards lower insulin levels, especially when fasting.
    • Age is a significant factor influencing insulin levels in children.
    • The findings contribute to establishing normative data for pediatric insulin secretion.

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