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Antibiotic-associated pseudomembranous colitis
Canadian Medical Association Journal
|January 22, 1977
Abstract:
Two cases of pseudomembranous colitis, one associated with administration of ampicillin and the other associated with administration of ampicillin and trimethoprim-sulfamethoxazole, are reported. Both patients presented with diarrhea, abdominal pain, fever and an elevated leukocyte count. Pseudomembranous colitis was diagnosed by sigmoidoscopy and biopsy. Both patients recovered with conservative management.
Insights
Two cases of pseudomembranous colitis were linked to ampicillin and trimethoprim-sulfamethoxazole. Both patients recovered with conservative management, highlighting antibiotic-associated colitis treatment.
Area of Science:
- Gastroenterology
- Infectious Diseases
- Pharmacology
Background:
- Antibiotic-associated colitis is a significant clinical concern.
- Pseudomembranous colitis can manifest following antibiotic administration.
- Specific antibiotics like ampicillin and trimethoprim-sulfamethoxazole have been implicated.
Observation:
- Two distinct cases of pseudomembranous colitis are presented.
- Case 1 involved ampicillin; Case 2 involved ampicillin and trimethoprim-sulfamethoxazole.
- Both patients exhibited symptoms including diarrhea, abdominal pain, and fever with elevated leukocytes.
Findings:
- Sigmoidoscopy and biopsy confirmed pseudomembranous colitis in both individuals.
- The diagnosis was established through direct visualization and histological examination.
- Laboratory findings included leukocytosis, indicative of an inflammatory response.
Implications:
- Conservative management strategies can be effective for antibiotic-associated pseudomembranous colitis.
- Early diagnosis and appropriate supportive care are crucial for patient recovery.
- Understanding antibiotic-specific risks informs clinical practice and patient counseling.