[Experimental study of the interferonogenic and antiviral activity of biologically active substances]

The results of screening of five national preparations for the interferon-inducing activity in white mice by various doses, schedules and routes of administration are presented. Their capacity to protect the animals against influenza, tick-borne encephalitis, and herpes viruses was evaluated. Cuthizon, zimosan, tiloron and its analogue IC-32 induced in mice endogenous interferon production in amounts from 40 to 640 IU50/ml. Tiloron, prodigiozin, and zimosan were found to be effective against influenza. Protective effect of zimosan in combination with polyguacyl was observed against tick-borne encephalitis.