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Related Experiment Videos

Cutaneous T-cell lymphoma: a review.

C F Winkler, P A Bunn

    Critical Reviews in Oncology/Hematology
    |January 1, 1983
    PubMed
    Summary

    Mycosis fungoides and Sezary syndrome are indolent lymphomas affecting T-cells. Advances in cell biology and immunology have improved understanding of these cutaneous T-cell lymphomas (CTCL), revealing insights into their malignant potential.

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    Area of Science:

    • Hematology and Oncology
    • Immunology
    • Dermatology

    Background:

    • Cutaneous T-cell lymphomas (CTCL) encompass a group of disorders characterized by T-lymphocyte proliferation with skin manifestations.
    • Mycosis fungoides and Sezary syndrome are uncommon, indolent malignant lymphomas primarily affecting males in their fifth decade.
    • Historically, knowledge of these conditions was limited to clinical and pathological features.

    Purpose of the Study:

    • To review current understanding of mycosis fungoides and Sezary syndrome, focusing on advancements in their study.
    • To explore the impact of new technologies on characterizing these cutaneous T-cell lymphomas.
    • To discuss the clinical behavior and pathological progression of CTCL.

    Main Methods:

    • Application of immunologic, cell biologic, and cytogenetic technologies.
    • Establishment of continuous T-cell cultures utilizing T-cell growth factor (TCGF).
    • Phenotypic and functional characterization of malignant T-cells using immunologic markers.
    • Prospective staging techniques including E-rosette cytology, cytogenetics, and electron microscopy.

    Main Results:

    • Discovery of TCGF enabling T-cell growth and clonal expansion analysis.
    • Identification of human T-lymphotropic virus (HTLV) in CTCL cell cultures, potentially linked to more virulent forms.
    • Characterization of the malignant CTCL cell as a 'helper/inducer' subtype.
    • Demonstration of significant extracutaneous involvement using advanced staging methods.

    Conclusions:

    • Technological advancements have significantly expanded the understanding of CTCL pathogenesis and behavior.
    • The 'helper/inducer' phenotype of the malignant T-cell provides insights into T-cell function and immunity.
    • CTCL behaves as an indolent lymphoma with a propensity for extracutaneous spread, often underestimated clinically.

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