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[Experimental studies of the liberation of plasminogen activator by DDAVP]
Folia Haematologica (Leipzig, Germany : 1928)
|January 1, 1984
Abstract:
Infusion of 0,4 micrograms DDAVP/kg for 30 min increased the plasminogen activator activity in blood of experimental animals (dog, rat, rabbit). The plasminogen activator releasing effect was also demonstrated in isolated perfused vascular preparations (pig ear, rat lung) at low doses (10(-9) - 10(6) mol/l). According to these results DDAVP is believed to attack directly the endothelial cell.
Insights
Desmopressin (DDAVP) infusion boosts plasminogen activator activity in animal blood and isolated blood vessels. This suggests DDAVP directly stimulates endothelial cells to release plasminogen activators.
Area of Science:
- Pharmacology
- Vascular Biology
- Hemostasis
Context:
- The study investigates the effects of Desmopressin (DDAVP) on the hemostatic system.
- Plasminogen activator activity is crucial for regulating blood clot breakdown (fibrinolysis).
- Understanding DDAVP's mechanism is vital for its therapeutic applications.
Purpose:
- To determine if DDAVP influences plasminogen activator activity.
- To elucidate the cellular targets of DDAVP in the vascular system.
- To explore the dose-dependent effects of DDAVP on vascular preparations.
Summary:
- Intravenous infusion of Desmopressin (DDAVP) at 0.4 micrograms/kg for 30 minutes significantly elevated plasminogen activator activity in dogs, rats, and rabbits.
- The plasminogen activator-releasing effect was observed in isolated perfused vascular tissues (pig ear, rat lung) at concentrations ranging from 10(-9) to 10(-6) mol/l.
- These findings indicate that DDAVP directly interacts with endothelial cells, stimulating the release of plasminogen activators.
Impact:
- Provides evidence for DDAVP's direct action on vascular endothelium.
- Contributes to understanding the pro-fibrinolytic effects of DDAVP.
- Informs potential therapeutic strategies involving DDAVP for hemostatic disorders.