Haloperidol pretreatment does not alter the Golgi staining of the striatum

Two series of Wistar rats were treated with Haloperidol and the striata were stained with two different modifications of the Golgi method. The experimental animals of the first series received a single dose of Haloperidol i.p. and were sacrificed half an hour after the injection. The experimental rats of the second series were treated chronically with Haloperidol, beginning with 5 mg/kg and increasing this dose daily 0.2 mg/kg to reach a final dose of 10 mg/kg after four weeks of treatment. There were no differences in the staining of both series of animals when compared with their controls, whatever modification of the Golgi method was employed. As these results contradict those of Danner and Pfister (1982) the possible reasons of such a discrepancy are discussed.