[Clinical studies on preoperative nonspecific immunological parameters and radical operation in stomach cancer]

Ratio of IgG Fc receptor positive T (Fc R(+) T) cell, PHA-induced blastogenesis and serum alpha 2-globulin ratio were examined in 90 preoperative cases with gastric cancer and were analyzed according to various stages of cancer and compared with normal controls. Moreover, on the basis of correlations among these parameters, operative radicality and prognosis were discussed. Fc R(+) T cell ratio was significantly elevated. PHA- blastogenesis was significantly reduced. Alpha 2-globulin ratio tended to increase as the stage progressed. A significant negative correlation was found between Fc R(+) T cell ratio and PHA- blastogenesis. In a scattergram indicating this correlation, the group of noncurative resection or exploratory laparotomy was divided into two areas, B1 and B2. The group of curative resection (A1) was located between B1 and B2, and the normal control group was located in the area common to B1 and A1, Cases succumbing to cancer within one year postoperatively were found to accumulate either in the area B2 or in the area B1 minus the area common with A1. No significant correlation was found between Fc R(+) T cell ratio and alpha 2-globulin ratio. However in a scatter gram, the almost same relationship between these three groups was noted. Thus it has suggested that postoperative prognosis (at least for two years) is good in cases which an immunological harmony among these parameters is maintained preoperatively.