Fibronectin in eosinophilic globules of Spitz's nevi

Nine cases of Spitz's nevi, compound type, that had large homogeneous eosinophilic globules at the dermo-epidermal junction were stained with anti-fibronectin antibodies by the biotin-avidin indirect immunofluorescence technique. Fibronectin was demonstrated in all nine cases. This study demonstrates that fibronectin, which is present in the extracellular matrix material, is also localized in a homogeneous pattern in the eosinophilic globules of the Spitz's nevi.