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Drug interactions with nitrendipine.

W Kirch, H J Hutt, H Heidemann

    Journal of Cardiovascular Pharmacology
    |January 1, 1984
    PubMed
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    This study investigated potential drug interactions with nitrendipine. Nitrendipine did not significantly affect digoxin or cimetidine, but increased digoxin levels and side effects when co-administered.

    Area of Science:

    • Pharmacology
    • Clinical Pharmacology
    • Drug Interactions

    Background:

    • Calcium channel blockers, like nifedipine, are known to interact with other medications.
    • Nitrendipine is a new calcium channel blocker.
    • Potential interactions with commonly prescribed drugs require investigation.

    Purpose of the Study:

    • To investigate the pharmacokinetic interactions of nitrendipine with digoxin, digitoxin, cimetidine, ranitidine, atenolol, metoprolol, and acebutolol.
    • To assess the impact of co-administration on nitrendipine and interacting drug levels.
    • To identify potential adverse effects arising from these combinations.

    Main Methods:

    • Six healthy male volunteers received nitrendipine monotherapy and combined treatments for one week.

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  • Plasma levels of nitrendipine and other drugs were measured.
  • Pharmacokinetic parameters including Cmax, AUC, and Clpl were calculated.

    • Main Results:

    • Cimetidine, ranitidine, digoxin, and digitoxin did not significantly alter nitrendipine pharmacokinetics.
    • Beta-blockers (metoprolol, acebutolol) also showed no significant influence on nitrendipine kinetics.
    • Atenolol tended to increase nitrendipine Cmax and decrease its oral plasma clearance (p > 0.05).
    • Co-administration of nitrendipine with digoxin led to increased digoxin plasma levels and side effects.

    Conclusions:

    • Nitrendipine does not significantly interact with H2 receptor antagonists or digitalis glycosides.
    • While beta-blockers generally do not affect nitrendipine kinetics, atenolol warrants further investigation.
    • Nitrendipine co-administration can increase digoxin levels and associated adverse effects, necessitating careful monitoring.