Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Receptor mediated pathways for interferon action: in vivo implications.

K E Mogensen, M T Bandu, F Vignaux

    Medical Oncology and Tumor Pharmacotherapy
    |January 1, 1984
    PubMed
    Summary

    Human interferon (IFN) activates cell surface receptors through two binding equilibria, influencing cellular responses. Understanding these interactions is key for effective IFN therapy and drug delivery.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Artificial intelligence-based prediction of neurocardiovascular risk score from retinal swept-source optical coherence tomography-angiography.

    Scientific reports·2024
    Same author

    [Ultra-widefield imaging of fundus albipunctatus discovered in a 30-year-old woman seen for night blindness].

    Journal francais d'ophtalmologie·2023
    Same author

    Women's reproductive span: a systematic scoping review.

    Human reproduction open·2022
    Same author

    Baseline sensitivity of T cells to alpha-IFN correlates with sustained virological response to IFN-based triple therapy in HCV infection.

    Journal of viral hepatitis·2014
    Same author

    The receptor of the type I interferon family.

    Current topics in microbiology and immunology·2007
    Same author

    A sub-population of high proliferative potential-quiescent human mesenchymal stem cells is under the reversible control of interferon alpha/beta.

    Leukemia·2007

    Area of Science:

    • Immunology
    • Cell Biology
    • Pharmacology

    Background:

    • Human interferon (IFN) interacts with high-affinity receptors on nucleated cells, initiating cellular responses.
    • IFN receptor activation is the initial step in multiple signaling pathways, some requiring sustained IFN presence.

    Purpose of the Study:

    • To characterize the binding equilibria of IFN to its cell surface receptors.
    • To explore the relationship between different binding equilibria and cellular responses to IFN.
    • To discuss in vivo implications for IFN pharmacokinetics and potential desensitization.

    Main Methods:

    • Utilized a model culture system to study IFN receptor activation.
    • Analyzed two distinct types of equilibrium binding: short-duration (receptor activation) and long-duration (second site activation).

    Related Experiment Videos

    Main Results:

    • Identified two distinct equilibrium binding phases for IFN receptors.
    • Demonstrated that cellular responses to IFN are determined by these specific binding equilibria.
    • Proposed that varying IFN concentrations in vivo could lead to target cell desensitization.

    Conclusions:

    • IFN receptor binding kinetics dictate cellular responses.
    • In vivo IFN administration requires consideration of pharmacokinetic distribution and potential desensitization.
    • Combined IFN species may exert a modulating effect on cellular responses.