A study of microangioneogenesis in wounds healing by secondary intention

A method is described for the study of microangioneogenesis in wounds healing by secondary intention. Standard skin defects were created on the backs of Sprague-Dawley rats and angiograms of the new vessels in the healing wounds were performed at subsequent time intervals. The technique allowed comparison of the rate of new vessel formation in wounds covered with a hydrogel surgical dressing with those healing without a dressing. It was found that the rate of new capillary formation was faster in the covered wounds.