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Diabetes mellitus in chronic active hepatitis and cirrhosis

M E Kingston, M A Ali, M Atiyeh

    Gastroenterology
    |September 1, 1984
    PubMed

    Insights

    Diabetes is highly prevalent in chronic liver disease patients in Saudi Arabia, affecting 44% of severe chronic active hepatitis and 40% of cirrhosis cases. This is linked to long-term insulin resistance in a genetically predisposed population.

    Area of Science:

    • Hepatology
    • Endocrinology
    • Metabolic Disorders

    Background:

    • Chronic liver diseases like hepatitis and cirrhosis are common.
    • Diabetes mellitus is a significant global health concern.
    • The relationship between chronic liver disease and diabetes requires further investigation.

    Purpose of the Study:

    • To determine the prevalence and characteristics of glucose intolerance and diabetes in patients with chronic active hepatitis, cirrhosis, chronic persistent hepatitis, and hepatoma.
    • To compare the prevalence of diabetes in liver disease patients with the general population and diabetic patients with liver disease.

    Main Methods:

    • Retrospective review of 293 patients with various liver conditions.
    • Analysis of fasting serum glucose levels to diagnose diabetes.
    • Assessment of glucose tolerance and insulin resistance.

    Main Results:

    • Diabetes prevalence was 8% in chronic persistent hepatitis/mild chronic active hepatitis, 44% in severe chronic active hepatitis, 40% in cirrhosis, and 15% in hepatoma.
    • Prevalence in liver disease patients (up to 44%) was significantly higher than in other patients (7%).
    • Glucose tolerance in chronic active hepatitis and cirrhosis showed basal hyperinsulinemia and insulin resistance.

    Conclusions:

    • A high prevalence of diabetes exists in patients with chronic active hepatitis and cirrhosis in Saudi Arabia.
    • Insulin resistance associated with chronic liver disease, over time, likely contributes to diabetes development in a genetically susceptible population.
    • Liver disease patients have a higher diabetes prevalence than diabetic patients have liver disease.

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