Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Many rhinovirus serotypes share the same cellular receptor.

G Abraham, R J Colonno

    Journal of Virology
    |August 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The Pattern of Care of Use of Nivolumab in Head and Neck Cancers - Audit From a Tertiary Cancer Centre.

    Clinical oncology (Royal College of Radiologists (Great Britain))·2021
    Same author

    Assessment of Plasma Zinc and Total Leukocyte Count in Calves Experimentally Infected with Mannheimia haemolytica.

    Biological trace element research·2020
    Same author

    Fungal empyema thoracis.

    QJM : monthly journal of the Association of Physicians·2020
    Same author

    Effect of Isothermic Dialysis on Intradialytic Hypertension.

    Indian journal of nephrology·2019
    Same author

    Statistical optimization of process parameters for improvement of phycobiliproteins (PBPs) yield using ultrasound-assisted extraction and its kinetic study.

    Ultrasonics sonochemistry·2019
    Same author

    An Unusual Association of Renal Cell Carcinoma and Renal Malakoplakia with Focal Segmental Glomerulosclerosis in an Elderly Patient.

    Indian journal of nephrology·2019

    Researchers identified that most human rhinovirus serotypes utilize a common cellular receptor for attachment. This finding suggests a shared vulnerability across many rhinovirus strains, impacting future therapeutic strategies.

    Area of Science:

    • Virology
    • Molecular Biology
    • Immunology

    Background:

    • Human rhinoviruses (HRVs) are a major cause of the common cold.
    • Previous studies characterized HRV properties, but receptor usage remained incompletely understood.

    Purpose of the Study:

    • To characterize the cellular receptor binding properties of 24 human rhinovirus serotypes.
    • To determine if HRV serotypes share common cellular receptors for attachment.

    Main Methods:

    • Purification of HRV serotypes using metrizamide density gradients.
    • Determination of binding conditions and saturation of cellular receptors.
    • Competition binding assays to assess receptor sharing among HRV serotypes.

    Main Results:

    Related Experiment Videos

    • Purified HRV preparations exhibited lower buoyant density and higher specific infectivity than previously reported.
    • Twenty out of 24 HRV serotypes bound to a common cellular receptor.
    • Four HRV serotypes demonstrated attachment to a distinct cellular receptor.

    Conclusions:

    • A common cellular receptor is likely utilized by the majority of human rhinovirus serotypes.
    • This shared receptor presents a potential target for broad-spectrum antiviral therapies against HRV infections.
    • Further research is warranted to explore the implications of distinct receptor usage by some HRV serotypes.