Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Immobilisation hypercalcemia.

R A Evans, M Bridgeman, E Hills

Mineral and Electrolyte Metabolism

|January 1, 1984

Summary

This summary is machine-generated.

Immobilisation hypercalcemia in patients may involve biologically inactive parathyroid hormone (PTH). Bone histology varies, and distinguishing it from primary hyperparathyroidism requires careful clinical evaluation.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Dynamic hyperinflation in patients with severe asthma compared to healthy adults.

Pulmonology·2023

Same author

New prebiotic chemistry inspired filter media for stormwater/greywater disinfection.

Journal of hazardous materials·2019

Same author

A mannose selection system for production of fertile transgenic maize plants from protoplasts.

Plant cell reports·2019

Same author

Efficacy of once-weekly dapsone dosing for Pneumocystis jirovecii pneumonia prophylaxis post transplantation.

Transplant infectious disease : an official journal of the Transplantation Society·2015

Same author

Cost and benefit of hospital, hospital- in- the- home and ambulatory care nutrition support services.

Asia Pacific journal of clinical nutrition·2014

Same author

Mathematical modeling of postmenopausal osteoporosis and its treatment by the anti-catabolic drug denosumab.

International journal for numerical methods in biomedical engineering·2013

Same journal

Proceedings of the 9th International Congress on Renal Nutrition and Metabolism. Vienna, Austria. August 29-September 1, 1998.

Mineral and electrolyte metabolism·2000

Same journal

Bioelectrical impedance analysis in dialysis patients.

Mineral and electrolyte metabolism·2000

Same journal

Nutritional status assessment and body composition analysis in pre-end stage renal disease patients.

Mineral and electrolyte metabolism·2000

Same journal

Long, slow dialysis.

Mineral and electrolyte metabolism·2000

Same journal

Nitric oxide/L-arginine in uremia.

Mineral and electrolyte metabolism·2000

Same journal

Advanced glycation end-product levels in subtotally nephrectomized rats: beneficial effects of angiotensin II receptor 1 antagonist losartan.

Mineral and electrolyte metabolism·2000

See all related articles

Area of Science:

Endocrinology
Nephrology
Bone Metabolism

Background:

Immobilisation hypercalcemia is a complex condition.
Understanding its biochemical and histological underpinnings is crucial for diagnosis.

Purpose of the Study:

To investigate the biochemical and bone histological characteristics of patients with immobilisation hypercalcemia.
To explore the role of parathyroid hormone (PTH) and its potential inactivity.

Main Methods:

Studied 5 patients with immobilisation hypercalcemia.
Measured plasma calcium, parathyroid hormone (PTH), and nephrogenous cyclic adenosine monophosphate (cAMP).
Performed quantitative bone histology.

Main Results:

Related Experiment Videos

Elevated plasma calcium levels were observed.

Elevated or inappropriately detectable PTH levels were noted in most patients.

Bone histology showed variable patterns, including increased resorption and altered bone formation rates.

Conclusions:

PTH may be biologically inactive in immobilisation hypercalcemia, with elevations potentially due to renal retention of fragments.
Bone histological findings are variable and not correlated with illness duration.
Clinical assessment is vital to differentiate from primary hyperparathyroidism.