The regulatory factors controlling murine erythropoiesis in vitro

In the mouse, control of the proliferation of erythroid precursors is complex and probably based on the sequential expression of membrane receptors for different regulator molecules during erythroid differentiation. Purified GM-CSF, G-CSF and multi-CSF are all able to initiate proliferation of the earlier erythroid precursors, the multi-CFC and BFU-E, and multi-CSF can stimulate the proliferation of erythroid precursors through all subsequent stages of differentiation. Erythropoietin acts as proliferative stimulus only for the terminal stages of erythropoiesis. There is as yet no evidence for the existence of a distinct BPA regulator with proliferative effects restricted to early erythroid precursors.