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Related Experiment Videos

Food intake: opioid/purine interactions.

S Wager-Srdar, A S Levine, J E Morley

    Pharmacology, Biochemistry, and Behavior
    |July 1, 1984
    PubMed
    Summary

    Adenosine and inosine suppress opioid-induced feeding in rats, while caffeine

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    Area of Science:

    • Neuroscience
    • Pharmacology
    • Behavioral Science

    Background:

    • Exogenous opioids like butorphanol tartrate (BT) and ethylketocyclazocine (EKC) are known to stimulate feeding in rats.
    • Purines, such as adenosine and inosine, are known to suppress feeding behaviors.

    Purpose of the Study:

    • To investigate the effects of purines (adenosine, inosine) and caffeine on opioid-induced feeding in rats.
    • To explore the interaction between purines, caffeine, and opioid receptors in regulating food intake.

    Main Methods:

    • Rats were administered butorphanol tartrate (BT) or ethylketocyclazocine (EKC) to induce feeding.
    • The effects of various doses and time points of adenosine, inosine, and caffeine on opioid-induced feeding were evaluated.
    • Naloxone was used to assess the involvement of opioid mechanisms in caffeine's effects on feeding.

    Main Results:

    • Adenosine and inosine significantly suppressed BT and EKC-induced feeding.
    • Caffeine's enhancement of food consumption was blocked by naloxone, suggesting an opioid mechanism.
    • Caffeine at a low dose (12.5 mg/kg) blocked the suppressive effects of adenosine and inosine on BT-induced feeding.
    • High-dose caffeine (50 mg/kg) suppressed BT-induced feeding, and this effect was reversed by adenosine and inosine.

    Conclusions:

    • Adenosine and inosine effectively suppress opioid-induced feeding.
    • Caffeine exhibits complex interactions with adenosine/inosine and opioid pathways in modulating feeding behavior.
    • Opioid mechanisms may play a role in caffeine's effects on food intake.

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