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Serum IgG, IgA and IgM in asthmatic children
African Journal of Medicine and Medical Sciences
|March 1, 1984
Summary
Serum immunoglobulin M (IgM) levels were lower in asthmatic children compared to controls. Immunoglobulin G (IgG) levels were higher in asthmatic children with positive skin tests, but overall immunoglobulin levels have limited diagnostic or severity grading value for childhood asthma.
Area of Science:
- Pediatric Allergy and Immunology
- Clinical Immunology
Background:
- Asthma is a common chronic respiratory disease in children.
- Immunoglobulin levels, including IgG, IgA, and IgM, play a role in immune function and may be altered in allergic conditions.
Purpose of the Study:
- To investigate serum immunoglobulin G (IgG), A (IgA), and M (IgM) levels in children with asthma.
- To assess the relationship between immunoglobulin levels, asthma severity, and skin sensitivity test results.
Main Methods:
- Quantitative analysis of serum IgG, IgA, and IgM levels.
- Comparison between 45 asthmatic children and 45 age-matched controls.
- Correlation analysis with asthma severity and skin sensitivity test results.
Main Results:
- No significant difference in mean IgG and IgA levels between asthmatic children and controls.
- Significantly lower mean IgM levels were observed in asthmatic children compared to controls, particularly in females.
- No correlation found between immunoglobulin levels and asthma severity.
- Higher mean IgG levels were found in asthmatic children with positive skin sensitivity tests.
Conclusions:
- Serum IgM levels may be altered in childhood asthma.
- Serum immunoglobulin levels (IgG, IgA, IgM) are of limited value for diagnosing asthma or grading its severity in children.
- Elevated IgG in asthmatics with positive skin tests warrants further investigation.