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Reversible interference with TCGF activity by virus particles.

M A Wainberg, S Vydelingum, M Boushira

    Clinical and Experimental Immunology
    |September 1, 1984
    PubMed
    Summary
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    Certain viruses, including retroviruses and herpes viruses, can hinder lymphocyte response to mitogens. This occurs because viruses bind to T-cell growth factor (TCGF) and inactivate it, a process that can be reversed.

    Area of Science:

    • Immunology
    • Virology
    • Cell Biology

    Background:

    • Viruses like retroviruses and herpes viruses can impair human lymphocyte function.
    • This impairment occurs even with inactivated viruses, suggesting infection-independent mechanisms.

    Purpose of the Study:

    • To investigate the mechanisms by which virus particles inhibit lymphocyte response to mitogenic stimuli.
    • To determine if viruses interfere with T-cell growth factor (TCGF) activity.

    Main Methods:

    • Co-incubation of human peripheral blood lymphocytes with various virus types.
    • Measurement of TCGF activity in cultures.
    • Interaction of viruses with purified TCGF, followed by complex separation via centrifugation.
    • Reversal of TCGF inactivation using mild detergent treatment.

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    Main Results:

    • Virus co-incubation led to reduced TCGF activity production.
    • Viruses directly complexed with TCGF, rendering it biologically inactive.
    • The virus-TCGF complex formation was reversible upon detergent treatment, restoring TCGF activity.

    Conclusions:

    • Virus particles can inhibit lymphocyte mitogenic responses through infection-independent mechanisms.
    • Direct binding and inactivation of TCGF by viruses is a key mechanism of immune suppression.
    • The reversibility of TCGF inactivation offers potential avenues for therapeutic intervention.