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Clostridium perfringens type C causing necrotising enteritis.

W P Severin, A A de la Fuente, M F Stringer

    Journal of Clinical Pathology
    |August 1, 1984
    PubMed
    Summary
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    A rare case of enteritis necroticans caused by Clostridium perfringens type C occurred in a 24-year-old man with diabetes. This finding highlights a new geographical association for this severe intestinal disease.

    Area of Science:

    • Gastroenterology
    • Infectious Diseases
    • Microbiology

    Background:

    • Enteritis necroticans is a severe intestinal disease.
    • Clostridium perfringens is a known bacterial cause.
    • Type C strains are typically associated with endemic regions.

    Observation:

    • A 24-year-old man with diabetes presented with rapidly fatal enteritis necroticans.
    • Clostridium perfringens type C was identified as the causative agent.
    • This case occurred outside of previously described endemic areas.

    Findings:

    • The study details a fatal case of enteritis necroticans in a non-endemic area.
    • Clostridium perfringens type C was confirmed as the pathogen.
    • The role of beta toxin in pathogenesis is discussed.

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    Implications:

    • This case expands the known geographical distribution of Clostridium perfringens type C-associated enteritis necroticans.
    • It underscores the potential for this pathogen to cause severe disease in individuals with underlying conditions like diabetes.
    • Further research into the factors contributing to non-endemic outbreaks is warranted.