Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Does interferon exert its actions through opiate receptors.

C Reyes-Vazquez, N Weisbrodt, N Dafny

    Life Sciences
    |August 27, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Age differences to methylphenidate-NAc neuronal and behavioral recordings from freely behaving animals.

    Journal of neural transmission (Vienna, Austria : 1996)·2022
    Same author

    Adolescent rats respond differently to methylphenidate as compared to adult rats- concomitant VTA neuronal and behavioral Recordings.

    Brain research bulletin·2022
    Same author

    Adult female rats' altered diurnal locomotor activity pattern following chronic methylphenidate treatment.

    Journal of neural transmission (Vienna, Austria : 1996)·2013
    Same author

    Adolescent rat circadian activity is modulated by psychostimulants.

    Brain research·2011
    Same author

    Psychostimulants given in adolescence modulate their effects in adulthood using the open field and the wheel-running assays.

    Brain research bulletin·2010
    Same author

    Bilateral six-hydroxydopamine administration to PFC prevents the expression of behavioral sensitization to methylphenidate.

    Brain research·2009

    Alpha interferon (alpha-IFN) was investigated for opiate receptor involvement. Studies found alpha-IFN excites cells, unlike morphine, and naloxone did not block these effects, refuting the opiate receptor hypothesis.

    Area of Science:

    • Neuroscience
    • Pharmacology

    Background:

    • Alpha interferon (alpha-IFN) has been reported to induce endorphin-like effects, including analgesia and catatonia.
    • These effects were previously observed to be reversible and preventable by naloxone, suggesting a potential mediation via opiate receptors.

    Purpose of the Study:

    • To investigate the hypothesis that alpha interferon's effects are mediated through opiate receptors.
    • To determine the interaction between alpha interferon, morphine, and naloxone on neuronal and smooth muscle preparations.

    Main Methods:

    • Extracellular cortical cell recording in guinea pigs.
    • Microiontophoretic application of alpha interferon, morphine, and naloxone.
    • Assessment of drug effects on the coaxially stimulated guinea-pig ileum preparation.

    Related Experiment Videos

    Main Results:

    • Alpha interferon application induced excitation in both cortical cells and the guinea-pig ileum.
    • Morphine primarily caused a decrease in activity in both preparations.
    • Naloxone reversed and prevented morphine's effects but did not alter the effects of alpha interferon.

    Conclusions:

    • The study failed to support the hypothesis that alpha interferon's effects are mediated via opiate receptors.
    • Observations suggest alpha interferon acts through a non-opiate receptor mechanism.
    • Further research is needed to elucidate the precise mechanisms of alpha interferon's actions.