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Related Experiment Videos

Case report: blastomycosis causing sciatic neuritis.

R Miller-Catchpole, J W Rippon

    Mycopathologia
    |June 30, 1984
    PubMed
    Summary
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    A rare case of Blastomyces dermatitidis bone infection in the ilium was diagnosed. Despite Amphotericin B treatment failure, the patient responded well to Ketoconazole therapy.

    Area of Science:

    • Mycology
    • Infectious Diseases
    • Radiology

    Background:

    • Osteomyelitis can present with non-specific symptoms.
    • Fungal osteomyelitis is uncommon, particularly in immunocompetent individuals.
    • Blastomycosis typically affects the lungs but can disseminate to bone.

    Observation:

    • A patient presented with right lower back and leg pain.
    • Imaging revealed a lytic lesion in the right ilium and sacroiliac joint.
    • Biopsy and culture confirmed Blastomyces dermatitidis infection.

    Findings:

    • The infection was localized to the right ilium and sacroiliac joint.
    • Two courses of Amphotericin B were ineffective.
    • Ketoconazole treatment led to a positive clinical response.

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    Implications:

    • This case highlights the importance of considering fungal infections in osteomyelitis, even with negative initial imaging.
    • It underscores the diagnostic utility of advanced imaging and biopsy.
    • The successful use of Ketoconazole suggests its potential role in refractory cases of Blastomyces bone infections.