Occurrence of a transposition from the X-chromosome long arm to the Y-chromosome short arm during human evolution

DXYS1, a site showing greater than 99% DNA sequence homology between the human X and Y chromosomes, maps to the X long arm and to the Y short arm. In great apes, sequences homologous to DXYS1 are found only on the X chromosome. These findings suggest an X-Y transposition during human evolution.