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Related Experiment Videos

Alternative RNA processing: determining neuronal phenotype.

M G Rosenfeld, S G Amara, R M Evans

    Science (New York, N.Y.)
    |September 21, 1984
    PubMed
    Summary
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    Alternative RNA processing allows the calcitonin gene to produce distinct peptides in the brain and thyroid. This process generates calcitonin gene-related peptide (CGRP) in the brain and calcitonin hormone in the thyroid.

    Area of Science:

    • Molecular Biology
    • Neuroscience
    • Endocrinology

    Background:

    • The calcitonin gene is known to produce the hormone calcitonin.
    • Tissue-specific expression of genes is crucial for organismal development and function.

    Purpose of the Study:

    • To investigate the molecular mechanisms underlying tissue-specific polypeptide synthesis from the calcitonin gene.
    • To identify novel peptides derived from the calcitonin gene.

    Main Methods:

    • Analysis of human and rat calcitonin genes.
    • Study of RNA processing and alternative splicing.

    Main Results:

    • Alternative RNA processing dictates tissue-specific synthesis of polypeptides from the calcitonin gene.

    Related Experiment Videos

  • The calcitonin gene generates two distinct messenger RNAs.
  • One mRNA encodes the precursor to calcitonin gene-related peptide (CGRP), prevalent in the brain.
  • The second mRNA encodes the precursor to calcitonin, prevalent in thyroid C cells.

    • Conclusions:

    • Alternative RNA processing is a key developmental strategy for generating tissue-specific peptides.
    • Calcitonin gene-related peptide (CGRP) is a novel neuropeptide with widespread distribution in the nervous and endocrine systems.
    • CGRP likely plays roles in pain perception, appetite regulation, cardiovascular control, and mineral metabolism.