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Modification of polymorphonuclear leucocyte function by imidazoles

B Rowan-Kelly, A Ferrante, Y H Thong

    International Journal of Immunopharmacology
    |January 1, 1984
    PubMed

    Insights

    Five imidazole derivatives were tested for their effects on human immune cells. Metronidazole and tinidazole showed no impact, while clotrimazole, miconazole, and ketoconazole impaired immune cell function and pathogen killing.

    Area of Science:

    • Immunology
    • Pharmacology
    • Microbiology

    Background:

    • Human polymorphonuclear leucocytes (PMNL) are crucial for innate immunity.
    • Imidazole derivatives are widely used as antifungal and antibacterial agents.
    • Understanding drug interactions with immune cells is vital for therapeutic efficacy.

    Purpose of the Study:

    • To investigate the in vitro effects of five imidazole derivatives on human PMNL functions.
    • To determine if these imidazole derivatives impact PMNL's ability to combat pathogens.

    Main Methods:

    • In vitro assessment of human PMNL.
    • Evaluation of PMNL chemotaxis in response to imidazole derivatives.
    • Assessment of PMNL's fungal and bacterial killing capacity after exposure to imidazole derivatives.

    Main Results:

    • Metronidazole and tinidazole did not affect PMNL chemotaxis or pathogen killing.
    • Clotrimazole, miconazole, and ketoconazole significantly inhibited PMNL chemotaxis.
    • Miconazole and ketoconazole also reduced the ability of PMNL to kill bacteria and fungi.

    Conclusions:

    • Certain imidazole derivatives (clotrimazole, miconazole, ketoconazole) can suppress key human PMNL functions.
    • This immunomodulatory effect may have clinical implications for patients undergoing treatment with these drugs.
    • Metronidazole and tinidazole appear to be safe regarding direct impact on PMNL functions.

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