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Updated: Aug 14, 2026

A Simple and Inexpensive Method for Determining Cold Sensitivity and Adaptation in Mice
Published on: March 17, 2015
Cold acclimation increases physiological responsiveness to intraventricular injection of beta-endorphin in
Abstract:
beta-endorphin administered intraventricularly into pentobarbital anaesthetized rats led to a reduction in rectal temperature and a dose dependent biphasic response in metabolic rate with increase at low doses (7-10 nmol/kg) and decrease at high doses (30-300 nmol/kg) in rats acclimated to 22 degrees. These metabolic responses to beta-endorphin were enhanced both in magnitude and in duration in rats acclimated to 5 degrees for 3 weeks, indicating an increased responsiveness to beta-endorphin. Naloxone antagonized the metabolic effects of beta-endorphin in rats acclimated to both 22 degrees and 5 degrees, indicating the metabolic effects of beta-endorphin were via the naloxone sensitive opiate receptors.

