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Genetic relationship between two enteroviruses causing the acute hemorrhagic conjunctivitis syndrome
Intervirology
|January 1, 1984
Summary
Singapore epidemic conjunctivitis (SEC) virus and enterovirus type 70 (EV70) show minimal genetic homology (≤2%). This indicates SEC virus is genetically distinct from EV70, the cause of acute hemorrhagic conjunctivitis (AHC) pandemics.
Area of Science:
- Virology
- Molecular Biology
- Epidemiology
Background:
- Acute hemorrhagic conjunctivitis (AHC) is a syndrome caused by enteroviruses.
- Enterovirus type 70 (EV70) caused major AHC pandemics globally between 1969 and 1972.
- Singapore epidemic conjunctivitis (SEC) virus has caused localized conjunctivitis epidemics since 1970.
Purpose of the Study:
- To genetically differentiate between the causative agents of AHC and localized conjunctivitis epidemics.
- To investigate the genetic relationship between EV70 and SEC virus.
Main Methods:
- RNA-RNA hybridization technique was employed to assess nucleotide sequence homology.
- Comparison of genetic material between EV70 (J670/71 strain) and SEC virus (EH 24/70 strain).
Main Results:
- A low nucleotide sequence homology (≤2%) was observed between EV70 and SEC virus.
- High homology (>90%) was found between the prototype EV70 strain and other EV70 isolates.
- EV70 and SEC virus are serologically and genetically distinct.
Conclusions:
- SEC virus is genetically distinct from EV70.
- The findings differentiate the etiological agents responsible for global AHC pandemics and regional conjunctivitis outbreaks.
- This distinction is crucial for understanding the epidemiology and control of different viral conjunctivitis diseases.