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ACTH 1-17 effects in chronic obstructive bronchitis.

G Costa, E Gaffuri, G Maranelli

    La Ricerca in Clinica E in Laboratorio
    |April 1, 1984
    PubMed
    Summary
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    Adrenocorticotropic hormone (ACTH) 1-17 treatment showed mixed results for chronic obstructive bronchitis patients, with some improving and others not. The treatment partially inhibited the hypothalamo-hypophyseal axis but maintained respiratory function rhythms.

    Area of Science:

    • Endocrinology
    • Pulmonology
    • Chronobiology

    Background:

    • Chronic obstructive bronchitis (COB) significantly impacts respiratory function and quality of life.
    • Understanding the effects of hormonal treatments on COB patients is crucial for developing new therapeutic strategies.
    • The hypothalamo-hypophyseal axis plays a role in physiological regulation, potentially influencing respiratory conditions.

    Purpose of the Study:

    • To evaluate the effectiveness of ACTH 1-17 in male patients with chronic obstructive bronchitis.
    • To assess the impact of ACTH 1-17 on ventilatory function, general condition, and circadian rhythms.
    • To investigate the effect of ACTH 1-17 on the hypothalamo-hypophyseal axis through plasma cortisol level monitoring.

    Main Methods:

    • 10 male COB patients received 100 mcg of ACTH 1-17 intramuscularly daily for 10 days.

    Related Experiment Videos

  • Spirometric tests recording 8 ventilatory parameters and oral temperature were performed every 4 hours for 14 days.
  • Plasma cortisol levels were measured 6 times daily before and after treatment.

    • Main Results:

    • 4 out of 10 patients showed improved ventilatory function; 7 reported a better general condition.
    • Circadian rhythms of respiratory function and temperature remained unaffected.
    • A significant reduction in plasma cortisol levels and a slight advance in acrophase indicated partial hypothalamo-hypophyseal axis inhibition.
    • Skin hyperpigmentation and weight increase were observed as side effects in some patients.

    Conclusions:

    • ACTH 1-17 demonstrated variable efficacy in improving ventilatory function in COB patients.
    • The treatment partially suppressed the hypothalamo-hypophyseal axis without disrupting respiratory or temperature circadian rhythms.
    • Individual patient responses varied, suggesting potential for dosage or timing optimization, and highlighting the need for further research into side effects.