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ACTH 1-17 effects in psychogenic impotence
La Ricerca in Clinica E in Laboratorio
|April 1, 1984
Summary
Adrenocorticotropic hormone (ACTH) 1-17 improved sexual function and restored testosterone rhythm in men with psychogenic impotence. This treatment also reduced anxiety and fatigability, showing positive chronopharmacological effects.
Area of Science:
- Endocrinology
- Sexual Medicine
- Chronopharmacology
Background:
- Psychogenic impotence affects adult men, impacting sexual and endocrine functions.
- Previous research has not fully elucidated the effects of ACTH 1-17 on male sexual and endocrine health.
Purpose of the Study:
- To investigate the effects of repeated ACTH 1-17 administration on sexual and endocrine function in men with psychogenic impotence.
- To assess the impact of ACTH 1-17 on hormone levels, including luteinizing hormone (LH), follicle-stimulating hormone (FSH), prolactin (PRL), testosterone (T), and cortisol.
Main Methods:
- A randomized controlled trial involving 20 adult men with psychogenic impotence.
- Treatment group received 100 micrograms of ACTH 1-17 intramuscularly daily for 15 days over 6 months; control group received saline.
- Clinical and endocrine evaluations, including serum hormone level measurements (LH, FSH, PRL, T, cortisol) and assessment of diurnal rhythms, were performed before and after treatment.
Main Results:
- ACTH 1-17 treatment significantly improved sexual function compared to placebo (p < 0.05).
- ACTH 1-17 administration reduced anxiety and fatigability.
- While basal hormone levels remained unaffected, ACTH 1-17 restored the diurnal rhythm of testosterone, which was absent pre-treatment.
Conclusions:
- ACTH 1-17 demonstrates a positive chronopharmacological effect on sexual function and circadian testosterone rhythm in men with psychogenic impotence.
- The findings suggest ACTH 1-17 as a potential therapeutic agent for psychogenic impotence, addressing both sexual function and hormonal rhythmicity.