Fluosol 43 particle localization pattern in target organs of rats. An electron microscopy study

Perfluorocarbons (PFCs), chemically inert fluorinated organic compounds with high binding capacity for O2, are under discussion as substitutes for erythrocytes. Given the paucity of E.M. observations after their use, the aim of this study was to provide more extensive ultrastructural data about PFC particle size in the emulsion and about the localization pattern in organs of rats after infusion of Fluosol 43. Attention has been focused on the particle relationships with subcellular structures and on the subsequent histopathological implications.