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SMON as seen from Bombay.

N H Wadia

    Acta Neurologica Scandinavica. Supplementum
    |January 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Clioquinol shows neurotoxic potential, with subacute myelopathy being the most common diagnosis in Bombay. The study investigated Subacute Myelo-Optic Neuropathy (SMON) cases in India between 1967-1976.

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    Area of Science:

    • Neurotoxicology
    • Neurology

    Background:

    • Clioquinol consumption in India is significant, yet new Subacute Myelo-Optic Neuropathy (SMON) cases have not been reported since 1977.
    • A neurotoxicology group conducted an inquiry in Bombay to gather information on SMON from 1967 to 1976.

    Purpose of the Study:

    • To review and analyze cases of suspected SMON in Bombay during a specific period.
    • To assess the neurotoxicity of clioquinol and understand the discrepancy in SMON prevalence between Japan and Bombay.

    Main Methods:

    • Retrospective search for two cases and prospective identification of seven cases.
    • Clinical diagnosis and electrophysiological assessment of neurological symptoms.
    • Review of patient data for myelopathy, neuropathy, and optico-myelopathy.

    Main Results:

    • Nine patients were diagnosed with varying degrees of SMON.
    • Myelopathy with distal dysesthesia was more common than classic SMON.
    • Pyramidal tract disturbances, spasticity, posterior column disorder, and sensory ataxia were observed.
    • Subacute myelopathy (6 patients), optico-myelopathy (2 patients), and myeloneuropathy (1 patient) were identified.

    Conclusions:

    • Clioquinol exhibits potential neurotoxicity.
    • The study highlights a significant difference in SMON prevalence between Japan and Bombay, with no clear explanation found.