Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Renal alpha adrenoceptors.

R J Summers

    Federation Proceedings
    |November 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Alpha adrenoceptors regulate kidney function, affecting blood flow and electrolyte balance. Both alpha 1 and alpha 2 subtypes are key, with distinct roles and locations within the kidney tubules.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Recent progress in the understanding of relaxin family peptides and their receptors.

    British journal of pharmacology·2017
    Same author

    Molecular pharmacology of G protein-coupled receptors.

    British journal of pharmacology·2016
    Same author

    Enhanced serelaxin signalling in co-cultures of human primary endothelial and smooth muscle cells.

    British journal of pharmacology·2015
    Same author

    Serelaxin-mediated signal transduction in human vascular cells: bell-shaped concentration-response curves reflect differential coupling to G proteins.

    British journal of pharmacology·2014
    Same author

    Signalling profiles of H3 relaxin, H2 relaxin and R3(BΔ23-27)R/I5 acting at the relaxin family peptide receptor 3 (RXFP3).

    British journal of pharmacology·2014
    Same author

    Editorial. Themed issue of the British Journal of Pharmacology.

    British journal of pharmacology·2014
    Same journal

    ASBESTOS FIBERS MEDIATE THE UPTAKE OF DNA INTO PRIMATE CELLS IN CULTURE.

    Federation proceedings·2018
    Same journal

    Chemical protection of mammalian tissues.

    Federation proceedings·2014
    Same journal

    Dietary requirements for fertility and lactation; dried yeasts as sources of proteins and vitamin B complex for growth, reproduction and lactation.

    Federation proceedings·2010
    Same journal

    On the mode of action of chlorinating compounds.

    Federation proceedings·2010
    Same journal

    d-Amino acid oxidase of Proteus morganii.

    Federation proceedings·2010
    Same journal

    Studies on thymus nucleohistone.

    Federation proceedings·2010
    See all related articles

    Area of Science:

    • Nephrology
    • Pharmacology
    • Molecular Biology

    Background:

    • Alpha adrenoceptors (α1 and α2) are crucial in regulating renal hemodynamics, electrolyte homeostasis, and kidney metabolism.
    • These receptors exhibit species-specific variations in distribution and molecular characteristics.
    • Understanding their localization is vital for comprehending renal physiology and pharmacology.

    Purpose of the Study:

    • To delineate the specific roles and localization of alpha 1 and alpha 2 adrenoceptor subtypes within the kidney.
    • To investigate species-specific differences in adrenoceptor expression and function.

    Main Methods:

    • Radioligand binding studies were employed to determine the distribution of adrenoceptors.
    • Comparative analysis across different species (rat and guinea pig) was performed.

    Related Experiment Videos

    Main Results:

    • Alpha 1 adrenoceptors primarily localize to proximal tubules, influencing blood flow, sodium reabsorption, and gluconeogenesis.
    • Alpha 2 adrenoceptors, which inhibit adenylate cyclase, show varied distribution; in rats, some are associated with glomeruli, while in both rats and guinea pigs, most are found on proximal tubules.
    • Species differences in alpha 2 adrenoceptor density and molecular features were observed.

    Conclusions:

    • Alpha 1 and alpha 2 adrenoceptors play distinct, yet overlapping, roles in renal function, predominantly within proximal tubules.
    • Species-specific expression patterns of alpha 2 adrenoceptors highlight the complexity of adrenergic regulation in the kidney.
    • Further research into these adrenoceptors could reveal novel therapeutic targets for renal diseases.