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Updated: Jul 31, 2026

Analysis of DNA Double-strand Break (DSB) Repair in Mammalian Cells
Published on: September 9, 2010
Genetic changes in mammalian cells reminiscent of an SOS response
Abstract:
Prior to the isolation of mammalian DNA repair genes and identification of their gene products, the comparison between the bacterial SOS response and various similar reactions in mammalian cells remains rather speculative. The increasing number of observed phenomena including enhanced DNA repair, virus induction, induced cellular differentiation, and neoplastic transformation, all following DNA damage or arrest of replication, are, however, suggestive of an SOS-like system of growth control and may form an entry into this fascinating area.
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