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[Fundamental study on ceftriaxone].

K Kawakita, T Ide, M Urabe

    The Japanese Journal of Antibiotics
    |June 1, 1984
    PubMed
    Summary
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    Ceftriaxone (CTRX) shows a shorter half-life in healthy individuals compared to patients with renal failure. Urinary excretion of CTRX is significantly reduced in renal failure patients, but it remains effective against E. coli.

    Area of Science:

    • Pharmacokinetics
    • Clinical Pharmacology
    • Infectious Diseases

    Background:

    • Ceftriaxone (CTRX) is a widely used antibiotic.
    • Renal impairment can significantly alter drug pharmacokinetics.
    • Understanding CTRX disposition in renal failure is crucial for safe and effective dosing.

    Purpose of the Study:

    • To investigate the blood levels and urinary excretion of Ceftriaxone (CTRX) in healthy individuals and patients with renal failure.
    • To assess the efficacy of CTRX against bacterial strains isolated from renal failure patients.
    • To evaluate the safety profile of CTRX in these populations.

    Main Methods:

    • Comparative pharmacokinetic study involving healthy volunteers and patients with renal failure.
    • Administration of 1g CTRX via intravenous injection or drip infusion.

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  • Measurement of blood levels and urinary excretion over specified periods.
  • In vitro susceptibility testing of CTRX against clinical isolates.

    • Main Results:

    • Healthy individuals exhibited an average blood half-life of 7.1 hours for CTRX.
    • Patients with renal failure showed reduced urinary excretion rates (13.7-27.9%) compared to healthy individuals (54.6%).
    • CTRX demonstrated effectiveness against E. coli isolated from renal failure patients, with no observed side effects.

    Conclusions:

    • Renal impairment significantly impacts CTRX pharmacokinetics, leading to reduced excretion.
    • CTRX remains a viable treatment option for infections caused by susceptible organisms like E. coli in patients with renal failure.
    • The study supports the continued use of CTRX in patients with renal impairment, pending further dose-adjustment studies.